After the trauma of seeing their own demise, Nancy and her team resolve to hatch a plan to put a halt to the Aglaeca's curse. As a mysterious girl, who was brutally assaulted, mentions Nancy's name before falling into a coma, Detective Tamura arrives at the Claw to interrogate Nancy.
The quest of Nancy and the Drew Crew for a way to defeat the Aglaeca leads them to a dangerous confrontation with the vindictive spirit of a drunk. After Nick's mother shows up unexpectedly, she expresses her displeasure with her son's relationship with George.
As Bess finds a way that might end the Aglaeca's curse, they come in contact with a strange character, a withdrawn horror writer, which brings about terrible events.
With the Aglaeca's wrath drawing closer, Nancy tries to convince her to let her and her friends live, but to no avail, whereupon the team desperately seeks to save themselves by annihilating her.
On the day before they're supposed to die, the Drew Crew are still looking for a way to kill the Aglaeca when it occurred to Nancy to try to appeal to Odette, the woman the Aglaeca used to be, which leads to adverse consequences.
While at the morgue for community service, Nancy comes across a strange corpse, which sends her on a new perilous mission, and as Carson offers his help, he asks for a favor in return. George makes a shocking discovery.
Following the disappearance of their teammate from a haunted hotel room, a girls' volleyball team enlists Nancy's help. As the Drew Crew investigates, Ace asks Amanda, who works at the hotel, for a favor, and briefly flirts with her before they're interrupted by Bess's alleged husband.
Stephen, Bess's alleged husband, blackmails her into stealing a precious heirloom. Meanwhile, looking to get rid of the ghost that's been possessing her, George, along with Nancy, tries to track down the former owner of the shroud that brought her back to life, only to find out startling truths.
As the shroud gets stolen, the Drew Crew wonders who might be the thief since nobody knows about it except them, only for Ace to drop a bombshell. Afterwards, they approach Gil Bobbsey and end up making a deal with him.
After a terrifying occurrence takes place at the flower shop, Nancy sets about investigating, and as she crosses paths with Gil along the way, he offers to help her, much to her surprise. Ace gets a message from his long-lost brother.
As an amnesiac Nick shows up at Nancy's door, the Drew Crew sets out to solve this mystery, while Nancy faces a crisis at home after Celia tells Ryan that Nancy is his daughter, unaware that he already knows.
As Ace is reunited with half-brother Grant, he gets entangled in a problem involving his mom, upon which he enlists the help of Nancy, whom Celia asks to recant her statement about Everett.
With her reputation suffering, Nancy decides to investigate one of her father's cases, which leads her, along with Ace and Amanda, to an uninhabited island. Meanwhile, Odette ruffles George's feathers, so the latter decides to retaliate.
While Nancy is having dinner with Carson on her birthday, the celebration is interrupted by Tamura, who places her under arrest on charges of contempt of court. Elsewhere, Bess, Ace, and George enlist the help of their ancestors while looking for the spirit of Odette's lover.
With eerie goings-on happening in Horseshoe Bay, a mysterious stranger called Tom Swift comes seeking Nancy's help to find a meteorite that hit the town many years ago.
As Everett tasks Nancy with a job fraught with riddles, Ryan and her friends take it upon themselves to prove Everett's crimes. Meanwhile, a concerned Carson tries to keep Nancy from going to the party she's been planning to attend.
As Nancy and Gil hold Everett captive, they confront him with Celia's death and try to get him to admit his crimes. Jake Cazine, a tenant of Nick's, files a complaint about Nick's youth center. Carson shows Nancy's unsettling photo to Bess.
As it becomes apparent that Nancy is possessed by a relentless wraith, Carson, Ryan, and her friends try to save her.