After serving eleven years in prison for the murder of his former rival, MacGruber is recruited by General Fasoose for one last suicide mission.
Captured by his arch-enemy Brigadier Commander Enos Queeth, MacGruber must escape or be tortured.
MacGruber and the team race to recover the deadly chemical weapon (Brimstone) before the bad guys can get their hands on it.
MacGruber and the team make a daring plan to go undercover at a party in Miami to prevent Queeth from carrying out his plan.
As Vicki gets closer to obtaining the Brimstone from the scientist Irina Poliskya, MacGruber stands in her way.
With the team in disarray, MacGruber attacks Queeth's massive complex in revenge.
As Queeth's evil plan continues, MacGruber must figure out who is behind the latest attacks.
With the team back together, MacGruber and the rest fight to survive and save the world from impending danger.